Pierre C. a écrit:
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"Only 200 mg per day of DHA for two weeks induced an antioxidant effect," they write. Taking 400 to 800 mg per day reduced the platelet function of these healthy men. Moreover, they concluded, taking 1 gram (1,000 mg) was less active against platelet activation and was "rather deleterious on redox status."
Docosahexaenoic acid (DHA) can prevent cardiovascular events. However, few studies have addressed the effects of DHA on both platelet reactivity and redox status in healthy subjects, and dose-related studies are scarce. The main objectives of the present study were to determine the effects of increasing doses of DHA on platelets and redox status in humans. Twelve healthy male volunteers (aged 53-65 yr) were assigned to consume an intake of successively 200, 400, 800, and 1600 mg/d DHA, as the only omega-3 fatty acid, for 2 wk each dose. Blood and urine samples were collected before and after each dose of DHA and at 8 wk after arrest of supplementation. DHA was incorporated in a dose-response fashion in platelet phospholipids. After supplementation with 400 and 800 mg/d DHA, platelet reactivity was significantly decreased. Platelet vitamin E concentration increased only after 200 mg/d DHA, while p38 MAP kinase phosphorylation decreased. Urinary isoprostane was also significantly lowered after 200 mg/d DHA but was increased after 1600 mg/d. Therefore, supplementation with only 200 mg/d DHA for 2 wk induced an antioxidant effect. It is concluded that low consumption of DHA could be an effective and nonpharmacological way to protect healthy men from platelet-related cardiovascular events.
OBJECTIVE: To determine the effect of supplementation with increasing doses of docosahexaenoic acid (DHA), as the only n-3 polyunsaturated fatty acid (PUFA), on low-density lipoprotein (LDL) redox status and oxidizability. METHODS: Twelve healthy men aged 53-65 years ingested consecutive doses of DHA (200, 400, 800 and 1600mg/day), each dose for two weeks. RESULTS: The proportions of DHA increased dose-dependently in LDL phospholipids and cholesteryl esters, even after two weeks of supplementation with 200mg/day DHA. The daily intake of 200, 400 and 800mg DHA resulted in increased alpha-tocopherol concentrations, decreased MDA concentrations, and a longer lag time for copper-induced LDL oxidation. Supplementation with 1600mg/day DHA had no effect on the above parameters. In plasma, concentrations of 4-hydroxy-hexenal, specifically derived from the peroxidation of n-3 fatty acids, significanty increased after 800 and 1600mg DHA, representing 0.01% of plasma n-3 PUFAs, while 4-hydroxy-nonenal concentrations, derived from the peroxidation of n-6 fatty acids, did not change. CONCLUSION: Our results clearly show that an intake of 200-800mg/day DHA may have protective and antioxidant effects on LDL and could represent optimal doses for cardiovascular disease prevention in a healthy population.
TourneBoules a écrit:Entre crever peinard dans son sommeil à 80 ans ou agoniser à 60 ans, mon choix est vite fait.
Moi.Looping a écrit:qui se lave les mains 20 fois par jour tant qu on y est?
j'essai d'enlever les barriere qui peuve empeché mon espri de s'élevé
Looping a écrit:qui se lave les mains 20 fois par jour tant qu on y est?
Looping a écrit:..ben après avoir tripoté ton clavier pour me répondre tu peux y retourner tellement c est crado !
Florian a écrit:Ahah.
Oui mais comment connaître les risques ? On ne sait pas ce qu'ils mettent dans les gélules... Que pensez des omega 3 bon marché de MP du coup ? Parce que ça fait quand même ch*er de prendre des Omega 3 dans une optique "santé" alors que les gélules peuvent être polluées... Le risque en vaut-il vraiment la chandelle ?
kobe24 a écrit:L'omega-6 tu en as déjà suffisamment dans ton alimentation, pas besoin d'en ajouter. Prend seulement des omega-3.
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