Je fais tourner Google à fond en ce moment et dans le cadre de recherche sur la Vit. C j'ai vu apparâitre le terme "Pycnogénol". Je me souviens que Seb en avait parlé il y a déjà un moment.
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Des avis ?
Plasma a écrit:Hier, j'ai fait ma première séance avec la supplémentation optimale selon Gromit : BCAA + Leucine + Taurine + Pycno + Arginine (sous forme "d'éthyl-ester" parce que j'ai un échantillon sous la main). Je ne sais pas si j'ai fait du muscle mais je me suis chopé une congestion du tonnerre !
International Journal of Impotence Research (2008) 20, 173–180; doi:10.1038/sj.ijir.3901597; published online 16 August 2007
Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial
R Stanislavov1, V Nikolova1 and P Rohdewald2
1. 1Department of Obstetrics and Gynecology, Medical University Sofia, Faculty of Medicine, Sofia, Bulgaria
2. 2Institute of Pharmaceutical Chemistry, Westfälische Wilhelms-Universität Münster, Münster, Germany
Correspondence: Professor Dr P Rohdewald, Institute of Pharmaceutical Chemistry, Westfälische Wilhelms-Universität Münster, Hittorfstr. 58–62, Münster, Germany. E-mail: rohdewa@uni-muenster.de
Received 17 April 2007; Revised 26 June 2007; Accepted 26 June 2007; Published online 16 August 2007.
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Abstract
In a randomly allocated, double-blind, placebo-controlled, crossover design, 50 patients with mild to moderate erectile dysfunction (ED) were treated for 1 month with placebo or a combination of L-arginine aspartate and Pycnogenol (Prelox). Patients reported sexual function from diaries. Testosterone levels and endothelial NO synthase (e-NOS) were monitored along with routine clinical chemistry. Intake of Pycnogenol for 1 month restored erectile function to normal. Intercourse frequency doubled. e-NOS in spermatozoa and testosterone levels in blood increased significantly. Cholesterol levels and blood pressure were lowered. No unwanted effects were reported. Prelox is a promising alternative to treat mild to moderate ED.
J Sex Marital Ther. 2003 May-Jun;29(3):207-13.
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Treatment of erectile dysfunction with pycnogenol and L-arginine.
Stanislavov R, Nikolova V.
Seminological Laboratory SBALAG, Maichin Dom, Sofia, Bulgaria. rstanik@abv.bg
Penile erection requires the relaxation of the cavernous smooth muscle, which is triggered by nitric oxide (NO). We investigated the possibility of overcoming erectile dysfunction (ED) by increasing the amounts of endogenous NO. For this purpose, we orally administered Pycnogenol, because it is known to increase production of NO by nitric oxide syntase together with L-arginine as substrate for this enzyme. The study included 40 men, aged 25-45 years, without confirmed organic erectile dysfunction. Throughout the 3-month trial period, patients received 3 ampoules Sargenor a day, a drinkable solution of the dipeptide arginyl aspartate (equivalent to 1.7 g L-arginine per day). During the second month, patients were additionally supplemented with 40 mg Pycnogenol two times per day; during the third month, the daily dosage was increased to three 40-mg Pycnogenol tablets. We obtained a sexual function questionnaire and a sexual activity diary from each patient. After 1 month of treatment with L-arginine, a statistically nonsignificant number of 2 patients (5%) experienced a normal erection. Treatment with a combination of L-arginine and Pycnogenol for the following month increased the number of men with restored sexual ability to 80%. Finally, after the third month of treatment, 92.5% of the men experienced a normal erection. We conclude that oral administration of L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with ED without any side effects.
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