Bonjour,
Herve D. a écrit:Pour ce qui est des haut dosage à but thérapeutique, montre moi des études clinique de qualité publiée dans une revue internationale avec comité de lecture.
je me répond mal poli que je suis, en cherchant un peu j'en ais trouvé que 2 études cliniques de haute dose de vit C dans le traitement du cancer qui avait le niveau requis, elles sont pas récentes et c'est pas très favorable :
http://www.ncbi.nlm.nih.gov/entrez/quer ... ids=384241
N Engl J Med. 1979 Sep 27;301(13):687-90.
Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial.
Creagan ET, Moertel CG, O'Fallon JR, Schutt AJ, O'Connell MJ, Rubin J, Frytak S.
One hundred and fifty patients with advanced cancer participated in a controlled double-blind study to evaluate the effects of high-dose vitamin C on symptoms and survival. Patients were divided randomly into a group that received vitamin C (10 g per day) and one that received a comparably flavored lactose placebo. Sixty evaluable patients received vitamin C and 63 received a placebo. Both groups were similar in age, sex, site of primary tumor, performance score, tumor grade and previous chemotherapy. The two groups showed no appreciable difference in changes in symptoms, performance status, appetite or weight. The median survival for all patients was about seven weeks, and the survival curves essentially overlapped. In this selected group of patients, we were unable to show a therapeutic benefit of high-dose vitamin C treatment.
et
http://www.ncbi.nlm.nih.gov/entrez/quer ... ds=3880867
N Engl J Med. 1985 Jan 17;312(3):137-41. Related Articles, Links
High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison.
Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ, Ames MM.
It has been claimed that high-dose vitamin C is beneficial in the treatment of patients with advanced cancer, especially patients who have had no prior chemotherapy. In a double-blind study 100 patients with advanced colorectal cancer were randomly assigned to treatment with either high-dose vitamin C (10 g daily) or placebo. Overall, these patients were in very good general condition, with minimal symptoms. None had received any previous treatment with cytotoxic drugs. Vitamin C therapy showed no advantage over placebo therapy with regard to either the interval between the beginning of treatment and disease progression or patient survival. Among patients with measurable disease, none had objective improvement. On the basis of this and our previous randomized study, it can be concluded that high-dose vitamin C therapy is not effective against advanced malignant disease regardless of whether the patient has had any prior chemotherapy.
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Hervé