Forums SuperPhysique

DavidL a écrit:à mettre environ 1g directement dans la bouche

Harvester a écrit:C'est ce que j'ai trouvé de plus pertinent sur ce sujet

Alban a écrit:DavidL : comme tu commences la créatine, ça serait intéressant que tu nous fasse part de tes sensations / résultats / évolution de la force sur les deux ou 3 premiers mois. Pour une fois on aurait un rapport d'utilisateur vierge en crétine en direct live.

Beber a écrit:
Au passage, deux petites questions :
- Combien de gramme fait une gelule de bcaa anabolique svp ?
- Combien de gramme fait une gelule de créatine svp ?

martino a écrit:beber tu risques de te faire lyncher!
esperons que mdg ou alban ne voit pas ton post lol

martino a écrit:va voir sur la fiche de ton produit nutrimuslce pour connaitre la quantité exacte sinon il y a la balance, de toutes facons ce n est pas au gramme pres de creatine ou de bcaa

Garfield a écrit:

DavidL a écrit:à mettre environ 1g directement dans la bouche

C'est "que" de la créatine pas des BCAA ou du bicarbonate de potassium

Alban a écrit:ça serait intéressant que tu nous fasse part de tes sensations / résultats / évolution de la force sur les deux ou 3 premiers mois. Pour une fois on aurait un rapport d'utilisateur vierge en créatine en direct live.

DavidL a écrit:

Garfield a écrit:

DavidL a écrit:à mettre environ 1g directement dans la bouche

C'est "que" de la créatine pas des BCAA ou du bicarbonate de potassium

Je n'ai pas compris pourquoi tu m'as répondu ça

Garfield a écrit:Car la créatine c'est neutre, les BCAA ou le bicarbonate de potassium c'est pas bon lol

Alban a écrit:Merci... mais sachant que toutes les semaines, ou quasiment, des machines à mouvement perpétuel sont brevetées, je préfèrerais voir les publis (dans revues à comité de lecture) originales

Je ne comprends pas non plus ce que vous voulez dire.

Alban a écrit:Pour une fois on aurait un rapport d'utilisateur vierge en crétine en direct live.

Since World War II one major bodybuilding trend has remained constant: Every year the athletes are both bigger and leaner. Obviously, the athletes who are the champions know some things that the others ignore.

In the early 1950s the few bodybuilders who were aware of the strong muscle-building effects of androgenic steroids got a serious edge in competition. As that secret leaked out, steroids became very popular, and the secret edge was no longer such a big secret. The only way to build even bigger muscles was to use increasingly more anabolics.

You can manipulate prostaglandin secretions for big gains. You don't do it with drugs but with special diet and training adjustments.

In the early '80s another secret muscle builder arrived-growth hormone. Although it was restricted to a few insiders at first, the word did eventually get out. In the mid '80s, clenbuterol came to the fore, followed by insulinlike growth factor 1 (IGF-1) in the early '90s.

The excitement caused by the arrival of IGF-1 hid what is probably a more potent muscle builder than any of those substances - prostaglandins (PGs). Today the anabolic effect of prostaglandins is the best-kept secret in the bodybuilding community. In fact, the so-called official word on prostaglandins is that they're potent mediators of catabolism, that they'll make you fat, that they're really bad for your health and so on. That's just not true, and you can manipulate prostaglandin secretions for big gains. You don't do it with drugs but with special diet and training adjustments.

Are Prostaglandins Harmful?

Why are prostaglandins made out to be the Saddam Hussein of bodybuilding? There are two reasons: 1) The insiders want to keep their edge-they don't want you to know about the benefits. 2) Some people don't have a clue as to what they're talking about. Some misconceptions about prostaglandins are easy to clear up. For example, we're told that PGs are antithermogenic, meaning they either reduce your temperature or prevent it from rising. That's the big lie. Think about the last time you got a fever. You probably took aspirin or ibuprofen. Why? As it happens, they're very potent prostaglandin inhibitors. If prostaglandins were truly antithermogenic, your temperature would have increased when you took aspirin or ibuprofen, but, amazingly, it reduced your body temperature. So much for the supposed antithermogenic effect.

Doctors recommend prostaglandin inhibitors to reduce fever simply because prostaglandins are the main mediators of thermogenic reactions, such as fevers. Any prostaglandin user will tell you they are the most powerful thermogenic mediators you can imagine. Some people, however, don't want you to remember that.

Most of the old formulas of ephedrine and caffeine contain aspirin. Supposedly, the aspirin's purpose is to enhance the thermogenic response of the stack, but I say it was added to those stacks so you'll have to buy another bottle.

The second piece of misinformation we get about PGs is that they're the mediators of muscle catabolism. If that were true, taking a simple prostaglandin inhibitor such as aspirin after training would make you big by slowing down catabolism. Well, no one ever got big by taking aspirin.

You might be thinking, If prostaglandins are such a powerful muscle builder, wouldn't taking aspirin make me smaller? As it happens, no one is aware of that side effect of aspirin. The explanation is simple. Physiological doses of aspirin cannot prevent the basal re leas of muscle prostaglandins and so don't interfere significantly with the normal protein turnover.

Weight training stimulates the local areas of prostaglandins enabling them to exert an even stronger anabolic influence. That means, however, that you can completely stall training-induced muscle growth if you take enough aspirin. I say enough aspirin because, as I just mentioned muscle prostaglandins are not as sensitive to the inhibitory effects of aspirin as the other prostaglandins are. Nevertheless, more powerful substances, such as glucocorticoids, have been shown to negatively affect muscle mass because of their potent inhibitory effects on the basal secretion of muscle prostaglandins. That's the reason an excess of cortisol is so bad for bodybuilders. By inhibiting the secretion of prostaglandins induced by proper training, cortisol hinders growth.

What Are Prostaglandins?

Some experts believe that prostaglandins are hormones, while others claim they are short-lived, lipid-related second messengers endowed with hormone-like effects. The latter is correct. They aren't truly hormones, but they're so close that for simplicity's sake I'll classify them as muscle-building, fat-reducing hormones.

The prostaglandins are derived from unsaturated fatty acids, so you might call them anabolic fats. By taking some kinds of dietary essential fatty acids, you can either increase or reduce prostaglandin secretions. At this point I'll restrict the discussion to muscle prostaglandins.

Every muscle is composed of many fibers, each of which is covered by a membrane made of fat. The fats you eat become the major components of the membrane, which not only protects the muscle cells but is also a source of phospholipids, the raw material of prostaglandins.

Proper weight training, for example, stimulates the local release of prostaglandins in an autocrine and paracrine manner. The more PGs that are released, the better. Some kinds of dietary fats can enhance the effect of training by providing more raw materials for prostaglandin synthesis, while others hinder the process. Consequently, you can enhance or slow down the release of those muscle-building substances by altering your fat intake, especially the kind of fat you take in.

For now I'll concentrate on the prostaglandins of the 1 series, which are called prostaglandin PGE1. PGE1 is created by the metabolization of linoleic acid, and one very easy way to increase the manufacture of PGE1 is to take oils that your diet doesn't naturally provide. In fact, most bodybuilders don't come close to producing enough PGE1.

The Anabolic Properties of PGE1

You may already be aware of some of PGE1's interesting properties. In the pre-Viagra era PGE1 injection was one of the most potent ways of inducing a long-lasting erection. PGE1 is also one of the few substances that can help build muscle mass. Its anabolic properties in humans were brought to light by German studies performed in the late '80s. The researchers gave PGE1 intravenously to healthy subjects who had fasted. Before the infusion, amino acids were leaving the muscles because of the catabolic response induced by the lack of food. Once the PGE1 got to the blood, the amino acid loss was stopped and then reversed. In other words, the subjects went from a state of net catabolism into a phase of net anabolism thanks to an increase in PGE1. Although insulin secretion was unchanged, the researchers concluded that PGE1 has an insulinlike effect on muscle. A recent study confirmed that effect.

The researchers begin by stating, "Prostaglandins of the E (PGE) series have long been considered 'catabolic' hormones, but recent data suggest that they may be secreted in critically ill patients to counteract stress hormones, stimulating protein synthesis." It's about time that science confirms what bodybuilders have known for years. If Dianabol is the breakfast of champions, PGE1 is their evening meal because of its ability to turn the catabolic nocturnal period into an anabolic period.

PGE1 deficiency has long been associated with impaired muscle growth. As humans naturally produce very little PGE1 because of a lack of absorption of the corresponding raw materials, bodybuilders are probably deficient in it-not in a way that's detrimental to their health but in the sense that muscle growth is suboptimal.

Will PGE1 Make You Fat?

As mentioned above, a high PGE1 level is especially desirable at night because of the substance's protective, insulinlike effects on muscles. Of course, with insulin there's also the possibility of gaining fat-and prostaglandins do have the reputation of being fattening.

PGE1 inhibits fat release in a test tube just as insulin does, but it's a big leap to assume that PGE1 is fattening based on test tube studies. In humans the administration of PGE1 leads to both an increase in the free fatty acid levels in the blood and an increased rate of fat oxidation in muscles. That means PGE1 extracts the fat from your adipose tissue and brings it to the muscles, where the fat molecules are burned. So much for PGE1 being fattening!

You may wonder how PGE1 produces its wonderful fat-burning effects. PGE1 actions in the short term are mediated mainly by an increase in the secretion of norepineprine. Its long-term fat-fighting effects are brought about by an increase in both growth hormone secretion and thyroid hormone production. In addition, PGE1 reduces the secretion of insulin that you'd normally get after a meal. That lessens insulin's fattening properties without altering its muscle-building effects, as those are reinforced by the PGE1.

PGE1 may also blunt the effects of the alpha 2 receptors, which is a good thing. Scientists believe it does that through a "heterologous desensitization at the post receptor level." That means the alpha 2 receptors located on the fat cells, which prevent fat loss, don't function as well because of PGE1. As a result, you lose more fat from hard- to-lose areas. What's more, PGE1 may enhance the fat-reducing properties of the beta adrenergic receptors.

PGE1 is also associated with fat cell necrosis, or the destruction of unwanted fat cells. Last, but not least, PGE1 strongly stimulates thermogenesis, which wastes calories. That, incidentally, is one of the major side effects of artificial PGE1 administration. Body temperature rises to an alarming degree.

In case you're wondering, there are no side effects involved with naturally enhanced PGE1 production. The problems arising from direct PGE1 infusion or taking PGE1 pills are due to the rapid, unnatural increase of the substance in the blood, and they range from fever to severe nausea, headache, cramps and soreness. In other words, exogenous administration of PGE1- in which it's introduced into the body from an outside source-is dangerous, and I strongly advise against it, especially as it's so simple to ask your body to produce it gently and naturally. That warning is particularly important for women, as the presence of exogenous PGE1 can damage a fetus.

How Do You Increase PGE1?

Use an oil rich in gamma linolenic acid (GLA, not to be confounded with CLA). Evening primrose oil (EPO) is one such oil. Although it's only 10 percent GLA, it has proven to be really good at elevating PGE1 levels. Five to 10 grams of EPO spread over the day is a good way to boost your PGEI level to muscle-building thresholds. Some studies done with humans have shown a fat-loss effect with far less than that, though. By taking GLA throughout the day, you enhance PGEJ production naturally, without the strong peaks associated with the side effects of drugs containing PGE1. The researcher in the last study cited above advised stacking GLA with zinc and vitamins C and B6 for optimal PGE1 transformation. 5 Unfortunately, throwing a few capsules of evening primrose oil into your diet is not enough for serious bodybuilders. It's a very good start, however, and in the next installment of this discussion I'll explain how you can fine-tune your dietary manipulation of the prostaglandins. By the way, flaxseed oil doesn't contain much GLA and if anything inhibits PGE1 formation.

If you're impressed with the prostaglandins so far, let me assure you that you ain't seen nothing yet. I consider PGE1 to be mild compared to PG of the 2 series, which can transform your physique as no steroid can in less than a week.

Note that it's very rare for someone to be able to increase the secretion of an anabolic factor with only a simple dietary manipulation, so don't miss this opportunity. I can't promise you'll get a Viagra-like effect, but you won't suffer the side effects either.

Prostaglandins (PG's), facts and other info...

Prostaglandins (PG's) are naturally occurring intercellular
messengers. In fact, many of the actions of anabolic substances fail
to exert their protein synthesis actions without them. It is a
clinical fact that there is a parallel between the rise of some levels
of PG's and the degradation of catabolism. So they may in part be the
relay between receptor-sites and translation to specific responses, or
secondary messengers.

Research has shown a rapid and quite strong direct anabolic action
from PG's in muscle cells. If PG's such as PGF-2 and PGE-2 are
introduced into muscle cells, protein synthesis occurs at an
incredible rate. If insulin is introduced into muscle cells with PGF-2
or PGE-2 there is a profound synergistic response.

This places certain PG's among the most potent of anabolic activators.
Perhaps far more so than anabolic steroids. This also suggests that
the powerful anabolic actions of IGF-1, insulin, and amino acids are
all mediated in one way or another by PG's.

Hang with me here. I need to explain your natural prostaglandin
production process. Some prostaglandins called the PGE 2 series are
made from a fatty acid found in the plasma membrane of your cells
called Arachidonic acid. Under basal or non-training conditions, most
of your arachidonic acid is in an esterified (bound) form inside the
membrane phospholipids.

Since only free (unbound) arachidonic acid can produce prostaglandins
of the PGE 2 series, the basal synthesis of them is low. Pretty much
like a balance of protein synthesis/degradation is normal
(homeostasis). Due to the action of an enzyme called phospholipase A2,
The esterified (bound) arachidonic acid is freed. The free arachidonic
acid is converted into PGE 2s by another group of enzymes called
Cyclooxygenase (COX).

COX-1 and COX-2 are both found inside most cells and are responsible
for the normal release of PG's. However, COX-2 is not normally present
in the cells during basal states. When you train (creating a stress)
COX-2 is quickly synthesized which in turn strongly stimulates
prostaglandin release. Some PG's are mediators of inflammation, but
our focus is upon PGF-2 which is an amazing anabolic stimulator.
(COX-2 specific inhibitors such as Celebrex do partially block this
activity).

Cortisol, both natural and synthetic, are powerful PG inhibitors,
though synthetic corticoids are even more powerful. Both reduce the
activity of COX-1, COX-2, and phospholipase A-2.

A note of interest before I babble on. Intense muscular activity
triggers specific muscle prostaglandins and the most intense of all
stimuli is pure negative reps with very heavy loads. If you choose an
exercise that contains a stretch position such as sissy-squats,
incline curls, etc., more growth specific PG's are produced.

The second most effective natural method of inducing elevated PG
production is intense muscular burn. This is because Lactic acid build-
up is a PG release stimulator.

Stretching is the third method. Stretching increases intermuscular
IGF-1 and FGF (fiber blast growth factor) which triggers PG
production.

Prostaglandins have shown up in a synthesized form on the black market
since a few years ago. I have personally seen amazing transformations
in those who had bravely injected PGF-2 site specifically 3-5 times
per day. The injections were administered directly into the muscle
group trained that day (usually with a fast-acting insulin such as
Humulin R or Humalog).

Due to extreme soreness, that body part could not be trained for a few
days following injections. Since PGF-2 is site-specific, abdominal
enlargement does not seem to occur as with IGF-1.

PGF-2 is the more active PG. Some of the elite group reported dramatic
muscular hypertrophy (growth) at a dosage of 1-2 mg each 3-5 times per
day. (3-10mg total per day) Side effects were serious soreness
throughout the muscle injected. (Like a major cramp far worse than
testosterone suspension).

It was commonly known to avoid injections of PGF-2 anywhere near the
intestines. (PGs of the 2 series will cause smooth muscles such as
intestines and stomach to contract majorly. Some have experienced the
worst bowel voiding of all times: the shits to end all shits) If
injected, a small amount of the PGF-2 would reach the blood stream.

This would explain the overall muscular growth reported. The reason,
as I have stated prior, the injections were so frequent is due to PG's
very short half- life.

As I wrote earlier, training and stretching trigger the release of
prostaglandins by acting on the 2 enzymes that are responsible for
their formation: Phospholipase A2 is increased which results in higher
formation of free (unbound) Arachidonic Acid within muscle cells. Then
muscular contractions increase COX-2, which transforms the freed
arachidonic acid into PG's.

The process can continue for days after a workout. At first, PGF-2 is
the most elevated of PG production. FGF-2 synthesis is also elevated
but in lower amounts at first. As the training induced muscle injury
heals, the amount of PGF-2 production increases progressively. (Which
is responsible for much of the anabolic reaction to training) It
should be noted that there are several different PG's including PGE-1
which is used as an erectile function drug injected directly into the
base of the penis. The result is a sort of inflammation: A woody.

The legal and far less effective but safer way to increase PG's is
from the increased intake of essential fatty acids (EFA's).
Specifically, Linoleic Acid, which is an OMEGA-6 fatty acid, and Alfa
Linolenic Acid which is an Omega-3 fatty acid. Gamma Linoleic Acid
(GLA) is another Omega-6 Fatty Acid essential for PGF-2 synthesizes.
EFA'S are not just health and performance related. These EFA's are so
necessary that without them, your body would simply deteriorate away
and you die.

I have been amazed at how lacking many new clients diets are in EFA's.
The best ratio seems to be 3:1, or about 6 grams of Omega-3 and 2
grams of Omega-6 fatty acids daily for most hard training
bodybuilders. The best supplemental source for both is hemp seed oil.
It contains the natural 3:1 ratio. Flax seed oil and evening primrose
oil are both good sources, the latter, an excellent GLA provider. Yes,
it is possible to test "dirty" for "weed" with enough hemp oil.

Notes: PG's are not stored like some hormones. They are quickly
synthesized and then quickly destroyed. There are no PG reserves.
Using androgens with PG'S were noted to be a bad idea for some
individuals even if a legal method could be found. Users often
reported that their muscles had difficulty functioning due to serious
pumps. The upside was that androgen cycles after PGF-2 cycles became
very effective again. According to some available literature, PGF-2
use seems to up- regulate androgen receptor counts at an amazing
rate.
PGF-2 prevented the fattening effects of insulin protocols by
differentiation while increasing TGF (*See TGF). This was a benefit
for those who were insulin resistant or during pre-contest periods.
In women PGF-2 use would induce severe menstrual cramping.
Arachidonic acid is found in red meat in fairly high levels.
Unfortunately the activity of an enzyme called 5-Lipooxygenase (5-LO)
upon arachidonic acid in the presence of estrogen has been linked to
prostate cancer. An interesting finding is that inhibition of the 5-LO
enzyme triggers massive apoptosis (programmed cell death) in human
prostate cancer cells. Ginger seems to inhibit this enzyme and omega-3
fatty acids have a protective effect against prostate cancer.

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